Transfer and intra-articular expression of the IL-1Ra cDNA in human rheumatoid joints

نویسندگان

  • CH Evans
  • PD Robbins
  • SC Ghivizzani
  • JH Herndon
  • MC Wasko
  • M Tomaino
  • R Kang
  • TA Muzzonigro
  • EM Elder
  • TL Whiteside
  • SC Watkins
چکیده

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Introduction & Objective: Interleukine-1 receptor antagonist (IL-1RA) is a powerful anti-inflammatory cytokine which limits the biological effects of IL-1. Due to structural similarity between IL-1 and its antagonist, IL-1RA competitively binds to IL-1 receptor which leads to no signal transduction. Therefore , it is applied in the treatment of patients with inflammatory diseases such as Rheu...

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Therapeutic gene transfer for rheumatoid arthritis.

Rheumatoid arthritis (RA) is a severe autoimmune systemic disease. Chronic synovial inflammation results in destruction of the joints. No conventional treatment is efficient in RA. Gene therapy of RA targets mainly the players of inflammation or articular destruction: TNF-alpha or IL-1 blocking agents (such as anti-TNF-alpha monoclonal antibodies, soluble TNF-alpha receptor, type II soluble rec...

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2001